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norskBlar i forfatter "Mathisen, Ulla Dorte"
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Ambulatory blood pressure as risk factor for long-term kidney function decline in the general population: a distributional regression approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-31)The results of randomized controlled trials are unclear about the long-term efect of blood pressure (BP) on kidney function assessed as the glomerular fltration rate (GFR) in persons without chronic kidney disease or diabetes. The limited duration of follow-up and use of imprecise methods for assessing BP and GFR are important reasons why this issue has not been settled. Since a long-term randomized ... -
Analgesic use in a Norwegian general population: Change over time and high-risk use - The Tromsø Study
(Journal article; Tidsskriftartikkel, 2015-06-06)Background: Increased use of analgesics in the population is a cause for concern in terms of drug safety. There is a paucity of population-based studies monitoring the change in use over time of both non-prescription (OTC) analgesics and prescription (Rx) analgesics. Although much is known about the risks associated with analgesic use, we are lacking knowledge on high-risk use at a population level. ... -
Blood pressure and age-related GFR decline in the general population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-28)Background: <br> Hypertension is one of the most important causes of end-stage renal disease, but it is unclear whether elevated blood pressure (BP) also accelerates the gradual decline in the glomerular filtration rate (GFR) seen in the general population with increasing age. The reason may be that most studies have considered only baseline BP and not the effects of changes in BP, antihypertensive ... -
Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)Purine metabolism is essential for all known living creatures, including humans in whom elevated serum concentration of purine break-down product uric acid (UA) is probably an independent risk factor for mortality, type 2 diabetes and cardiovascular events. An automated multiplex assay that measures several purine metabolites could therefore prove useful in many areas of medical, veterinary and ... -
Elevated blood pressure is not associated with accelerated glomerular filtration rate decline in the general non-diabetic middle-aged population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-14)Although hypertension is a risk factor for end-stage renal disease, this complication develops in only a minority of hypertensive patients. Whether non-malignant hypertension itself is sufficient to cause reduced glomerular filtration rate (GFR) is unclear. We investigated whether elevated blood pressure (BP) was associated with accelerated GFR decline in the general population. The study ... -
Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ... -
Estimated GFR is biased by non-traditional cardiovascular risk factors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-23)Background: Estimated glomerular filtration rate (eGFR) based on either cystatin C or creatinine perform similarly in estimating measured GFR, but associate differently with cardiovascular disease (CVD) and mortality. This could be due to confounding by non-GFRrelated traits associated with cystatin C and creatinine levels. We investigated non-GFRrelated associations between eGFR and two types ... -
Impaired Fasting Glucose Is Associated With Renal Hyperfiltration in the General Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6–6.9 mmol/L), elevated HbA1c, or hyperinsulinemia are associated with hyperfiltration ... -
Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29) -
Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29)Background: The role of prediabetes as a risk factor for hyperfiltration and albuminuria in persons who do not develop diabetes is unclear. The lack of evidence is mainly due to the difficulty of accurately assessing the glomerular filtration rate (GFR) in the near-normal range of GFR. We investigated whether prediabetes is an independent risk factor for glomerular hyperfiltration and high-normal ... -
Sex Differences in Age-Related Loss of Kidney Function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-30)Background - CKD is more prevalent in women, but more men receive kidney replacement therapy for kidney failure. This apparent contradiction is not well understood.<p> <p>Methods - We investigated sex differences in the loss of kidney function and whether any sex disparities could be explained by comorbidity or CKD risk factors. In the Renal Iohexol Clearance Survey (RENIS) in northern Europe, ...
